“We’ve explored the potential interaction of various tautomers salen with SARS-CoV-2 proteins to identify the most preferred tautomeric form of the studied molecule in terms of the effectiveness in interaction with proteins. According to scientists, salen – the substance at the photo – is relatively simple and inexpensive to synthesize. Such a process is called tautomerization, and the participants in this process are tautomers or tautomeric forms. Each of these hydrogen atoms can move to nitrogen atoms, thereby forming different shapes of the molecule. Metal complex compounds of salen derivatives are also actively used as catalysts.Īs a part of salen contains two “fluid” hydrogen atoms of hydroxyl groups. This is an organic compound which is capable to coordinate some metals, stabilizing them in different oxidation states. Salen itself as well as its derivatives are important ligands in many fields of practical application. The term “salen” refers to a tetradentate Schiff base, derived from salicylaldehyde and ethylenediamine. “We found out that salen can potentially interact with the studied proteins, and the best results were obtained for the non-structural protein nsp14, which protects the virus from destruction”, says Damir Safin, Research Engineer at the Organic Synthesis Laboratory of Ural Federal University. We tried to assess the potential activity of this compound against a series of proteins of the SARS-CoV-2, which cause the Covid-19 disease. “Our study focused on a well-known compound, salen. The results of the study are published in the Polycyclic Aromatic Compounds. The new finding can be useful for new drugs creation and effective treatments for coronavirus infection. Scientists used the method of molecular docking and discovered, that salen shows activity to the non-structural protein nsp14, which prevents the destruction of the virus. Researchers found out that salen is able effectively bind a number of proteins of the coronavirus SARS-CoV-2. The findings pave the way for developing new therapeutics to fight coronavirus. Summary: The compound Salen effectively binds to a number of SARS_CoV_2, the virus that causes COVID-19, proteins.
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